Basement membrane hydrogels dampen CAR-T cell activation: nanofibrillar cellulose gels as alternative to preserve T cell function in 3D cell cultures.
Sonia Aristín Revilla, Alessandro Cutilli, Eugenia Cambiaso, Dedeke Rockx-Brouwer, Cynthia Lisanne Frederiks, Marc Falandt, Riccardo Levato, Onno Kranenburg, Caroline A. Lindemans, Paul James Coffer, Victor Peperzak, Enric Mocholí, Marta Cuenca
This study shows that nanofibrillar cellulose hydrogels preserve T cell function better than Matrigel or basement membrane extract in 3D cultures.
iScience · Jul 30, 2025Peer-reviewedImmunology