Paul James Coffer

Site-dependent Treg cell transcriptional reprograming in a metastatic colorectal cancer model holds prognostic significance

The paper identifies location-specific transcriptional differences in tumor-infiltrating Treg cells across CRC metastases and links these to poor patient prognosis.

CD4+ T cell activation is dependent on a novel form of ULK1/2-independent autophagy

This study identifies a novel form of autophagy in CD4+ T cells that is independent of ULK1/2 and occurs alongside mTORC1 activation, supporting proliferation and cytokine production.

Basement membrane hydrogels dampen CAR-T cell activation: nanofibrillar cellulose gels as alternative to preserve T cell function in 3D cell cultures.

This study shows that nanofibrillar cellulose hydrogels preserve T cell function better than Matrigel or basement membrane extract in 3D cultures.

Glycolytic reprogramming shapes the epigenetic landscape of activated CD4+ T Cells in Juvenile Idiopathic Arthritis

This study shows that glycolytic reprogramming in JIA CD4+ T cells drives epigenetic changes linked to inflammation, with potential therapeutic implications.

Tumor-derived colorectal cancer organoids induce a unique Treg cell population through direct modulation of CD4+ T cell differentiation.

This study shows CRC tumor organoids induce Treg cells via TGFβ-dependent differentiation, with distinct transcriptional profiles and prognostic relevance in CRC patients.

IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration

This study shows IFNγ reprograms intestinal epithelial organoids to secrete CXCL11, which enhances T cell migration without affecting T cell activation.