High-throughput Genome Wide CRISPR Knock Out mechanical sort identifies genes driving metastatic cancer cell softening
Katherine M Young, Curtis N. Dobrowolski, Nicholas E. Stone, Kalina Paunovska, Sydney Bules, Kelly Ahkee, James Hankish, Alex Chapman, James E. Dahlman, Todd Sulchek, Cynthia A. Reinhart‐King
This study uses CRISPR knockout and mechanical sorting to identify genes affecting cell stiffness in ovarian cancer, finding three genes linked to increased stiffness and patient survival.
bioRxiv · Feb 12, 2026 · PreprintBioengineering