Cynthia A. Reinhart‐King

The paper develops a model linking matrix stiffness and ligand density to cellular bioenergetics in cancer cells, showing how mechanical forces influence metabolic pathways and contractility.

This study uses CRISPR knockout and mechanical sorting to identify genes affecting cell stiffness in ovarian cancer, finding three genes linked to increased stiffness and patient survival.

This study identifies ACTN4 as a non-muscle α-actinin in cardiac sarcomeres, showing it regulates contractility, hypertrophy, and heart remodeling without disease hallmarks.