Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB
Amandah Necker‐Brown, Mahmoud Mostafa, Andrei Georgescu, Andrew J. Thorne, Priyanka Chandramohan, Cora Kooi, Keerthana Kalyanaraman, Alex Gao, Akanksha Bansal, Sarah K. Sasse, Anthony N. Gerber, Richard Leigh, Robert Charles Newton
This study investigates how inflammatory cytokines like IL-1β and TNF induce IRF1 expression in human pulmonary epithelial cells through NF-κB activation, revealing potential mechanisms in glucocorticoid-resistant diseases.
PLoS ONE · Dec 8, 2025Peer-reviewedMolecular Biology