Anthony N. Gerber

Air pollutant multiomics improves functional annotation of SNPs associated with lung disease

The paper identifies airway epithelial transcriptional mechanisms linked to air pollutant exposure and lung disease risk using a functional genomics pipeline, highlighting hyaluronic acid metabolism and TOMM7 regulation as potential therapeutic targets.

Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB

This study investigates how inflammatory cytokines like IL-1β and TNF induce IRF1 expression in human pulmonary epithelial cells through NF-κB activation, revealing potential mechanisms in glucocorticoid-resistant diseases.

Integrated Genomics Approaches Identify Mediators of Transcriptional and Epigenetic Responses to Afghan Desert Particulate Matter in Human Small Airway Epithelial Cells

The paper uses ATAC-seq and PRO-seq to study transcriptional and epigenetic responses to Afghan desert particulate matter in human small airway epithelial cells, identifying key pathways and transcription factors involved.

Genomics-based deconvolution of multiplexed transcriptional responses to wood smoke particles defines rapid AHR signaling dynamics.

The paper uses genomics techniques to analyze transcriptional responses to wood smoke particles and identifies rapid AHR signaling dynamics and interactions with NFkB.

Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression

The paper uses GRO-seq to show glucocorticoids rapidly repress transcription without local GR occupancy and induce anti-inflammatory effects through GR-NF-kB cooperation.