Rutin derived microbiota metabolite 3,4 dihydroxybenzoic acid restores antibiotic susceptibility in XDR Gram negative pathogens with a system wide susceptibility signature
Tanim Islam, Phurt Harnvoravongchai, Alex Kidangathazhe, Sushim Kumar Gupta, Akhilesh Ramachandran, Ravi Jadeja, Joy Scaria
This study identifies 3,4-dihydroxybenzoic acid (DHBA), a rutin metabolite, as a potent antibiotic potentiator that restores susceptibility in XDR Gram-negative pathogens through a system-wide genetic susceptibility signature.
bioRxiv · Dec 26, 2025 · PreprintMicrobiology