Joy Scaria

An endolysin-expressing probiotic attenuates Clostridioides difficile infection in germ-free and dysbiotic microbiota-associated mice

This study shows that an engineered probiotic expressing an endolysin reduces Clostridioides difficile infection in mice with disrupted microbiota.

Rutin derived microbiota metabolite 3,4 dihydroxybenzoic acid restores antibiotic susceptibility in XDR Gram negative pathogens with a system wide susceptibility signature

This study identifies 3,4-dihydroxybenzoic acid (DHBA), a rutin metabolite, as a potent antibiotic potentiator that restores susceptibility in XDR Gram-negative pathogens through a system-wide genetic susceptibility signature.

Robust Colonization of Nasal Microbiota Across the Respiratory Tract and the Gut Modulates Innate Immune Response in a Germ-Free Pig Model

This study investigates how nasal microbiota colonization in germ-free pigs affects immune responses and gut-lung axis interactions, showing antibiotic disruption of microbial diversity and immune gene expression.

Emergent metabolic interactions in resistance to Clostridioides difficile invasion

The paper identifies key microbial interactions and metabolic pathways that confer resistance to C. difficile invasion using synthetic and clinical communities.

Geography Shapes the Population Genomics of Salmonella enterica Dublin

This study analyzes the population genomics of Salmonella enterica Dublin, finding that geographical regions shape its genomic structure and antibiotic resistance profiles.