DNA-PK facilitates HIV transcription by regulating the activity of RNA polymerase II and the recruitment of transcription machinery at HIV LTR
Sonia Zicari, Geetaram Sahu, Larisa Dubrovsky, Lin Sun, Han Yue, Tejaswi Jada, Alex Ochem, Michael Bukrinsky, Gary Leonard Simon, Mudit Tyagi
This study shows DNA-PK supports HIV transcription by regulating RNA polymerase II activity and transcription machinery recruitment at HIV LTR, leading to enhanced gene expression and replication.
bioRxiv · Aug 10, 2017 · PreprintMolecular Biology