5-hydroxymethylcytosines regulate gene expression as a passive DNA demethylation resisting epigenetic mark in proliferative somatic cells
Alex Wei, Hongjie Zhang, Qi Qiu, Emily B. Fabyanic, Peng Hu, Hao Wu
This study shows that 5-hydroxymethylcytosine (5hmC) can regulate gene expression as an epigenetic mark in somatic cells, but not drive active DNA demethylation through replication-dependent dilution.
bioRxiv · Sep 26, 2023 · PreprintGenomics