Qi Qiu

The paper integrates single-cell and spatial multiomic data to show widespread reactivation of developmental programs in diseased human hearts, with insights into transcriptional factors and localized fetal reactivation.

This study shows that H2BE is required for activity-dependent gene expression and homeostatic scaling in neurons.

scNT-seq2 improves time-resolved single-cell RNA sequencing by enhancing sensitivity and scalability for studying transcriptional dynamics.

This study identifies H2BE as a widely expressed H2B variant that enhances chromatin accessibility in neurons, promoting synaptic gene expression and long-term memory.

This study shows that an ENL mutation disrupts kidney development by altering gene regulation, leading to developmental defects and early death in mice, and suggests potential therapeutic strategies.

This study shows that 5-hydroxymethylcytosine (5hmC) can regulate gene expression as an epigenetic mark in somatic cells, but not drive active DNA demethylation through replication-dependent dilution.

This study develops snhmC-seq to quantify 5hmC in single cells and identifies non-canonical gene regulation by non-CG 5hmC in mouse brain.

This study identifies two epidermal transcriptomes and a transient dermal niche in eccrine gland development using single nucleus transcriptomics in mice.

This paper introduces scNT-Seq, a method to measure newly-transcribed and pre-existing RNAs in single cells, revealing gene regulatory networks and RNA dynamics in neurons and embryonic stem cells.