Peng Hu

This study shows that 5-hydroxymethylcytosine (5hmC) can regulate gene expression as an epigenetic mark in somatic cells, but not drive active DNA demethylation through replication-dependent dilution.

This study develops snhmC-seq to quantify 5hmC in single cells and identifies non-canonical gene regulation by non-CG 5hmC in mouse brain.

This study identifies two epidermal transcriptomes and a transient dermal niche in eccrine gland development using single nucleus transcriptomics in mice.

This paper introduces scNT-Seq, a method to measure newly-transcribed and pre-existing RNAs in single cells, revealing gene regulatory networks and RNA dynamics in neurons and embryonic stem cells.

This study uses scRNA-seq to reveal a novel multi-hormone cell cluster and lineage plasticity in the adult mouse pituitary under physiological stress.

sNucDrop-Seq isolates nuclei from adult mouse brains to analyze cell-type composition and neuronal activity states at single-nucleus resolution.