Mycobacterial RNase E cleaves with a distinct sequence preference and controls the degradation rates of most Mycolicibacterium smegmatis mRNAs
Ying Zhou, Huaming Sun, Diego A. Vargas-Blanco, María Carla Martini, Abigail R. Rapiejko, Michael R. Chase, Samantha R. Joubran, Alexa B. Davis, Joseph P. Dainis, Jessica M. Kelly, Thomas R. Ioerger, Louis A. Roberts, Sarah M. Fortune, Scarlet S. Shell
This study defines the role of RNase E in mRNA degradation in Mycolicibacterium smegmatis, showing it limits degradation of 89% of protein-coding genes and has distinct sequence preferences compared to gram-negative bacteria.
bioRxiv · Mar 14, 2023 · PreprintMolecular Biology