Author

Diego A. Vargas-Blanco

Worcester Polytechnic InstituteORCID 0000-0002-3559-2902Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Huaming SuniD· 2 shared Jessica M. KellyiD· 2 shared Scarlet S. ShelliD· 2 shared Ying ZhouiD· 2 shared Abigail R. RapiejkoiD· 1 shared Alexa B. Davis· 1 shared Catherine S. Masiello· 1 shared Dmitry KorkiniD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMolecular Biology

Huaming SunORCID

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2 papers

Recent·Most cited

Diverse intrinsic properties shape transcript stability and stabilization in Mycolicibacterium smegmatis

Huaming Sun, Diego A. Vargas-Blanco, Ying Zhou, Catherine S. Masiello, Jessica M. Kelly, Justin K. Moy, Dmitry Korkin, Scarlet S. Shell

This study identifies transcript properties influencing stability and stabilization in Mycolicibacterium smegmatis under different growth conditions using mRNA degradation profiling and machine learning.

NAR Genomics and Bioinformatics · Sep 28, 2024Peer-reviewedMolecular Biology

Mycobacterial RNase E cleaves with a distinct sequence preference and controls the degradation rates of most Mycolicibacterium smegmatis mRNAs

Ying Zhou, Huaming Sun, Diego A. Vargas-Blanco, María Carla Martini, Abigail R. Rapiejko, Michael R. Chase, Samantha R. Joubran, Alexa B. Davis, Joseph P. Dainis, Jessica M. Kelly, Thomas R. Ioerger, Louis A. Roberts, Sarah M. Fortune, Scarlet S. Shell

This study defines the role of RNase E in mRNA degradation in Mycolicibacterium smegmatis, showing it limits degradation of 89% of protein-coding genes and has distinct sequence preferences compared to gram-negative bacteria.

bioRxiv · Mar 14, 2023 · PreprintMolecular Biology