Molecular Noise-Filtering in the β-adrenergic Signaling Network by Phospholamban Pentamers
Daniel Koch, Alexander Alexandrovich, Florian Funk, Ay Lin Kho, Joachim P. Schmitt, Mathias Gautel
The paper shows that PLN pentamers act as noise-filters in β-adrenergic signaling by regulating monomer phosphorylation and stabilizing SERCA activity despite PKA activity fluctuations.
Cell Reports · Jul 1, 2021Peer-reviewedSystems Biology