Ay Lin Kho

The generation and validation of a de novo-designed titin binder for use in fluorescence microscopy

The paper designs and validates a de novo protein binder for the titin M10 domain, demonstrating its utility in fluorescence microscopy without antibodies.

A comprehensive framework for the interpretation of TTN missense variants

The paper presents a framework for interpreting TTN missense variants by integrating clinical, computational, and functional evidence, identifying two variants as likely pathogenic.

Molecular Noise-Filtering in the β-adrenergic Signaling Network by Phospholamban Pentamers

The paper shows that PLN pentamers act as noise-filters in β-adrenergic signaling by regulating monomer phosphorylation and stabilizing SERCA activity despite PKA activity fluctuations.