Biphasic Mechanical Loading Disrupts Cytoskeletal Symmetry in 3D Architected Scaffolds
Kailin Chen, Alexander Bolanos-Campos, Mistica Lozano Perez, Erin Berlew, Tianbai Wang, Luc Capaldi, Ran N. Tao, Arnold J. T. M. Mathijssen, Joel D. Boerckel, Ottman A. Tertuliano
This study shows that cyclic mechanical loading disrupts cytoskeletal symmetry in 3D scaffolds by combining matrix strain and fluid shear stress.
bioRxiv · Aug 4, 2025 · PreprintBioengineering