Joel D. Boerckel

This study shows that denervation in neonatal mice impairs musculoskeletal growth, altering cell proliferation and mechanotransduction gene programs in tendons and muscles.

This paper demonstrates that coupling nanoscale biointerface features with micro- and macro-scale scaffold architecture synergistically enhances osteogenesis in 3D-printed gyroid scaffolds.

This study shows that altering synovial cell mechanotransduction drives OA-like disease without joint injury, with partial effects on symptoms versus structural damage.

This study introduces an optogenetic tool to control RhoA signaling termination and shows it is faster than passive disactivation, revealing an asymmetry between activation and termination kinetics.

This study shows that osteocyte perilacunar/canalicular remodeling (PLR) during lactation is spatially heterogeneous and persists after weaning, indicating that tissue-level recovery does not fully restore osteocyte-level changes.

This paper develops a degeneration-inspired Voronoi scaffold platform to model osteoporotic bone microenvironments and demonstrates that surface engineering can restore osteogenic function in compromised scaffolds.

This paper uses CRISPR-mediated conditional mutagenesis to show BMP/GDF signaling restricts postnatal bone overgrowth by regulating both periosteal and endosteal osteoblasts.

This study shows maternal exercise rescues skeletal defects in fetal akinesia by directly stimulating fetal joint and bone development through mechanical forces.

This study shows that erythroid precursors in the bone marrow increase local oxygen levels after injury, promoting tissue repair by enhancing angiogenesis and osteogenesis.

This study identifies moesin's role in osteoclast fusion and function, showing its impact on bone resorption and disease therapy.

This study identifies YAP and TAZ as regulators of periosteal expansion during fracture repair, showing their role in cell proliferation and BMP4 regulation.

This study shows that cyclic mechanical loading disrupts cytoskeletal symmetry in 3D scaffolds by combining matrix strain and fluid shear stress.

This paper identifies Prg4+ fibro-adipogenic progenitors in muscle as critical for bone fracture repair by transforming into bone cells and promoting healing.

This study examines postnatal bone development in goats, showing rapid cortical bone densification and unique postnatal synostosis in metacarpal epiphyses.

This study shows that Cyr61 delivery enhances angiogenesis during bone fracture repair, particularly in fractures with stable fixation, and may have therapeutic potential for poor vascularization.

This study shows YAP and TAZ regulate osteoblast precursor mobilization and angiogenesis during bone development, linking mechanical cues to vascular and bone formation.

The paper identifies small molecule regulators of biological pathways by matching compound effects to known pathway phenotypes in public cell image data.

The paper develops a model showing how dynamic self-reinforcement of gene expression leads to cellular mechanical memory, linking mechanical history to long-term phenotypic changes.

This study shows YAP and TAZ promote periosteal osteoblast precursor expansion and differentiation to accelerate bone fracture healing.

This study shows YAP and TAZ redundantly promote bone development by regulating collagen I expression and organization through TEAD4 binding.