Serotonergic Polypharmacology of 2-Halogenated Tryptamines
Jeanine Yacoub, Elena Bray, Jude Bayyat, Grant C. Glatfelter, Alex Leake, Emilia M Buitrago, Alexander D. Maitland, John S. Partilla, Natalie G. Cavalco, Serena S. Schalk, Josie C Lammers, Michael H. Baumann, John D. McCorvy, James W. Leahy, Danielle Gulick, , Jacqueline L. von Salm
This study designs and tests 2-halogenated tryptamines to reduce psychoactive and cardiotoxic effects while retaining therapeutic serotonergic activity.
bioRxiv · Apr 21, 2026 · PreprintPharmacology & Toxicology