John D. McCorvy

This study designs and tests 2-halogenated tryptamines to reduce psychoactive and cardiotoxic effects while retaining therapeutic serotonergic activity.

This study examines the cardiovascular effects of microdosing LSD in mice and finds no significant risk despite 5-HT2B receptor activation.

This study evaluates three MDMA bioisosteres for improved pharmacological profiles, finding reduced off-target receptor activity and altered hepatic metabolism compared to MDMA.

The paper identifies 5-HT2A receptor signaling pathways that determine psychedelic potential using selective ligands and behavioral assays in mice.

This study identifies TRPC5 as a mediator of inflammatory mechanical pain using knockout mice and pharmacological inhibitors, showing its role in pain behaviors induced by lysophosphatidylcholine.