Author

Alexander J. Hinbest

Wesleyan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Rich OlsoniD· 3 shared Alexis Moreau· 2 shared Carey D. NadelliD· 2 shared Emma Gerace· 2 shared Jing Quan YaniD· 2 shared Ranjuna WeerasekeraiD· 2 shared Anthony Zamora· 1 shared Dang H. NguyeniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

Rich OlsonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structure of a key adhesin-exopolysaccharide interaction provides insights into matrix assembly in Vibrio cholerae biofilms

Alexander J. Hinbest, Hyerim Bianca Nam, Ewelina D. Liszczyk, Rajan Kandel, Emma Gerace, Alexis Moreau, Ranjuna Weerasekera, Ryan Gordon, Yiyan Yang, Jack Chen, Nathan Fowler, Xiaofang Jiang, Robert J. Woods, Jing Quan Yan, Rich Olson

This study determines the structure of Bap1 bound to VPS and shows how it facilitates biofilm adhesion and VPS organization through a conserved β-propeller interaction.

bioRxiv · Aug 4, 2026 · PreprintMicrobiology

Vibrio cholerae interaction with predatory bacteria on chitin suggests an alternative mode of biofilm formation in marine snow conditions

Jacob D. Holt, Katherine A. Miller, Olivia F. Hunter, Emily Rong Zhang, Alexander J. Hinbest, Emma Gerace, Rich Olson, Daniel E. Kadouri, Carey D. Nadell

This study shows that chitin-bound biofilms of Vibrio cholerae are less protected against predatory bacteria than glass-bound biofilms, altering predator-prey dynamics through changes in biofilm architecture.

bioRxiv · Oct 31, 2025 · PreprintMicrobiology

Surface remodeling and inversion of cell-matrix interactions underlies community recognition and dispersal in Vibrio cholerae biofilms

Alexis Moreau, Dang H. Nguyen, Alexander J. Hinbest, Anthony Zamora, Ranjuna Weerasekera, Katherine Matej, Xuening Zhou, Sandra Sánchez, Ignacio A. Rodriguez-Brenes, Jung‐Shen B. Tai, Carey D. Nadell, Wai‐Leung Ng, Vernita Diane Gordon, Natalia L. Komarova, Rich Olson, , Jing Quan Yan

This study shows that Vibrio cholerae biofilms undergo surface remodeling and inversion of cell-matrix interactions, shifting from attractive to repulsive as biofilms age, which facilitates dispersal.

Nature Communications · Jan 2, 2025Peer-reviewedBiophysics