Jing Quan Yan

This study determines the structure of Bap1 bound to VPS and shows how it facilitates biofilm adhesion and VPS organization through a conserved β-propeller interaction.

This study determines the near-atomic structure of Vibrio cholerae's sheathed flagellum and reveals its dynamic architecture and membrane-coupled mechanisms.

This study characterizes the physical properties and conformational dynamics of Vibrio cholerae exopolysaccharides to understand their role in biofilm matrix mechanics.

This study investigates how environmental salts modulate the aggregation and adhesion of a Vibrio cholerae peptide, revealing surface- and ion-dependent film formation mechanisms.

The paper investigates how a Vibrio cholerae peptide binds lipids through a β-hairpin conformation, contributing to biofilm adhesion and host colonization.

This paper develops a bacteria-mimetic bioadhesive using a Vibrio cholerae-derived peptide to achieve strong, non-covalent mucus adhesion and drug delivery.

This paper shows that Pseudomonas aeruginosa maintains monoflagellation via the FleQ-FleN circuit, and hyperflagellation leads to fitness defects, suggesting regulatory plasticity enables adaptive evolution of flagellar configurations.

The paper uses single-cell imaging to show phenotypic sorting and bet-hedging in Vibrio cholerae biofilms through c-di-GMP level differences.

This study analyzes the distribution, diversity, and evolution of biofilm matrix clusters and proteins across Vibrio species, revealing structural and evolutionary patterns of key genes.

This study shows that Vibrio cholerae biofilms undergo surface remodeling and inversion of cell-matrix interactions, shifting from attractive to repulsive as biofilms age, which facilitates dispersal.

This study identifies RbmB as a polysaccharide lyase that cleaves Vibrio cholerae VPS, contributing to biofilm dispersal and suggesting its potential as an antibacterial enzyme.