A critical role of epithelial MHCII in initiation of autoimmune tumorigenesis and sustaining premalignancy growth in the stomach
Clarisel Lozano, Emily N. Vazquez, Alexander Kolev, Amanda M. Honan, Wael M. El-Rifai, Alexander Zaika, Zhibin Chen
This study shows epithelial MHCII drives autoimmune tumorigenesis in the stomach by promoting cancer-associated markers and premalignant growth, and its removal reverses early gastric premalignancy.
bioRxiv · Apr 3, 2026 · PreprintImmunology