Author

Alexander Makriyannis

Northeastern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Aashish ManglikiD· 1 shared Alan AshworthiD· 1 shared Allan I. BasbaumiD· 1 shared Brian K. ShoichetiD· 1 shared Bryan L. RothiD· 1 shared Christos Iliopoulos‐TsoutsouvasiD· 1 shared Da ShiiD· 1 shared Fangyu LiuiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Aashish ManglikORCID

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1 paper

Recent·Most cited

Toward a Random Background for Ligand Optimization

Xinyu Xu, Olivier Mailhot, G.J. Correy, XP Huang, Joao M. Braz, Da Shi, Karthik Srinivasan, Kara Zielinski, Yuliia Holota, Yuliia Kuziv, Christos Iliopoulos‐Tsoutsouvas, Nathan D. Levinzon, Yagmur Umay Doruk, Moira M. Rachman, Morgan E. Diolaiti, , Brian K. Shoichet

This study systematically evaluates the effectiveness of random small perturbations in ligand optimization, finding 11.2% of analogs improved potency by ≥10-fold but often had worse pharmacokinetics.

bioRxiv · May 13, 2026 · PreprintPharmacology & Toxicology