Author

Xinyu Xu

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Brian K. ShoichetiD· 2 shared Christos Iliopoulos‐TsoutsouvasiD· 2 shared Harald HübneriD· 2 shared Moira M. RachmaniD· 2 shared Peter GmeineriD· 2 shared Aashish ManglikiD· 1 shared Alan AshworthiD· 1 shared Alexander M. GarcesiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Brian K. ShoichetORCID

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Author profile →

4 papers

Recent·Most cited

Library docking for Cannabinoid-2 Receptor ligands

Moira M. Rachman, Christos Iliopoulos‐Tsoutsouvas, Michael Dominic Sacco, Xinyu Xu, Cheng-Guo Wu, Emma Santos, Isabella Glenn, Lu Paris, Michelle K. Cahill, Suthakar Ganapathy, Tia A. Tummino, Yurii S. Moroz, Dmytro S. Radchenko, Meri Okorie, Vivianne L. Tawfik, , Brian K. Shoichet

This study uses library docking to identify subtype-selective CB2 receptor ligands, finding improved hit rates and affinities with larger libraries and structure-based optimization.

Journal of Medicinal Chemistry · Jul 3, 2026Peer-reviewedBiochemistry

Toward a Random Background for Ligand Optimization

Xinyu Xu, Olivier Mailhot, G.J. Correy, XP Huang, Joao M. Braz, Da Shi, Karthik Srinivasan, Kara Zielinski, Yuliia Holota, Yuliia Kuziv, Christos Iliopoulos‐Tsoutsouvas, Nathan D. Levinzon, Yagmur Umay Doruk, Moira M. Rachman, Morgan E. Diolaiti, , Brian K. Shoichet

This study systematically evaluates the effectiveness of random small perturbations in ligand optimization, finding 11.2% of analogs improved potency by ≥10-fold but often had worse pharmacokinetics.

bioRxiv · May 13, 2026 · PreprintPharmacology & Toxicology

Foxp4+ Mandibular Skeletal Stem Cells Orchestrate Bone/Tooth Development and Regeneration

L J Zhang, Dandan Cao, X Li, Hongqiang Yu, Jianfang Wang, Qiaoling Zhu, Xinyi Zhang, Chen Chen, Gongchen Li, Xinyu Xu, Xiaoqiao Xu, Dike Tao, Xuyan Gong, Pingping Niu, XC Wu, , Yao Sun

This study identifies Foxp4+ mandibular skeletal stem cells (mdSSCs) that drive bone/tooth development and regeneration, showing their therapeutic potential in regenerating mandibular structures.

bioRxiv · May 1, 2026 · PreprintCell Biology

The role of intrinsically disordered domains in regulating G protein coupled receptor signaling

Jun Zhi Xu, Ruoyi Qiu, Alexander M. Garces, Harald Hübner, Xinyu Xu, Chengyu Hao, Dorothée Weikert, Peter Gmeiner, Michael T. Lerch, Brian K. Kobilka

This study uses single-molecule imaging to show how agonist-specific dynamics in structured and disordered regions of the 2AAR regulate signaling and function.

Journal of the American Chemical Society · Dec 27, 2025Peer-reviewedBiophysics