Author

Yuliia Holota

Enamine (Ukraine)ORCID 0009-0009-2329-7111Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

A. Pashchenko· 1 shared Aashish ManglikiD· 1 shared Alan AshworthiD· 1 shared Alexander Makriyannis· 1 shared Allan I. BasbaumiD· 1 shared Alpha A. LeeiD· 1 shared Anton HlaviniD· 1 shared Anton Tkachenko· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperPharmacology & Toxicology

A. Pashchenko

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintMay 13, 2026

Toward a Random Background for Ligand Optimization

Xinyu Xu, Olivier Mailhot, G.J. Correy…·Brian K. Shoichet

This study systematically evaluates the effectiveness of random small perturbations in ligand optimization, finding 11.2% of analogs improved potency by ≥10-fold but often had worse pharmacokinetics.

DOI 10.64898/2026.05.10.724162

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintAug 8, 2025

Structure-Activity Relationship Studies Towards Analogues of Pleconaril as Novel Enterovirus-D68 Capsid-Targeting Antivirals

David L. Cousins, Ed Griffen, Jessica Stacey…·Kris M. White

The paper investigates structure-activity relationships of pleconaril analogues against EV-D68, identifying compounds with antiviral activity and favorable ADME properties.

DOI 10.1101/2025.08.08.668114

experimental assaydrug response / drug discovery

𝕏 PostBluesky