Reproducible autosomal gene expression changes with loss of typical X and Y complement across tumor types
Seema B. Plaisier, Robert Phavong, Mason Farmwald, Mariah C. Lee, Teagen Allen, Malli Swamy, Ilsa Rodriguez, MacKenzie Wells, Nadia Phaneuf, Susan Christine Massey, Jared Del Rosario, Juvelyn Hart, Alexander Mangelsdorf, Martin Van Der Jagt, Alex R. DeCasien, , Melissa A. Wilson
The paper examines gene expression changes in tumors with altered sex chromosome complements and finds associations with poorer survival and reduced sex-based gene expression differences.
bioRxiv · Sep 24, 2025 · PreprintCancer Biology