Low-dose ketamine tilts the cortical excitation--inhibition balance irrespective of systemic physiological response
Judith Kunze, Justus Student, Sarah Tune, Henrik Oster, Stefanie Schmidt, Harald Ihmsen, Alexander Tzabazis, Benedikt Lorenz, Carla Nau, Jonas Obleser
The paper shows low-dose ketamine shifts cortical excitation-inhibition balance toward excitation, with effects robust to cardiovascular responses, while propofol has the opposite effect.
bioRxiv · Sep 21, 2026 · PreprintNeuroscience