TGFβ primes alveolar-like macrophages to induce type I IFN following TLR2 activation
Sean M. Thomas, Abigail P. McGee, Taryn E Vielma, Laurisa M Ankley, Alexander W Rapp, Kayla N. Conner, Francois LeSage, Christopher Tanner, Eleanor C. Scheeres, Joshua J. Obar, Andrew J. Olive
This study shows TGFβ primes alveolar-like macrophages to induce type I IFN responses upon TLR2 activation through mitochondrial ROS and IRF3/7.
The Journal of Immunology · May 1, 2026Peer-reviewedImmunology