Joshua J. Obar

This study shows that Pseudomonas aeruginosa CF isolate DH1137 reduces inflammasome activation and IL-1β release in alveolar macrophages under hypoxia, potentially aiding immune evasion in cystic fibrosis.

The paper shows that dsRNA mycoviruses in Aspergillus fumigatus enhance MDA5/MAVS signaling and reduce virulence in chronic allergic aspergillosis.

This study shows TGFβ primes alveolar-like macrophages to induce type I IFN responses upon TLR2 activation through mitochondrial ROS and IRF3/7.

This study identifies iron overload and metabolic reprogramming in myeloid cells as drivers of susceptibility to Aspergillus fumigatus in influenza-associated pulmonary aspergillosis.

This study uses single-cell lineage tracing to show that CD8 T-cell clones exhibit differential fate commitment during acute infection, with some clones adopting memory or effector biases over time.