Andrew J. Olive

This study shows that Pseudomonas aeruginosa CF isolate DH1137 reduces inflammasome activation and IL-1β release in alveolar macrophages under hypoxia, potentially aiding immune evasion in cystic fibrosis.

This study shows that macrophages clear Klebsiella pneumoniae via iNOS-mediated RNS, not NOX2-generated ROS, highlighting a key role for iNOS in bacterial clearance.

This study uses a CRISPR screen to identify host genes critical for early Brucella infection in human macrophage-like cells, revealing shared and pathogen-specific dependencies.

This paper develops a model of myeloid-derived alveolar-like macrophages (MAMs) to study their function compared to fetal liver-derived AMs, finding they are more inflammatory due to metabolic and epigenetic differences.

The paper shows that dsRNA mycoviruses in Aspergillus fumigatus enhance MDA5/MAVS signaling and reduce virulence in chronic allergic aspergillosis.

This study shows TGFβ primes alveolar-like macrophages to induce type I IFN responses upon TLR2 activation through mitochondrial ROS and IRF3/7.

This study identifies Synaptotagmin 1 and 7 as facilitators of MR1-mediated antigen presentation of Mycobacterium tuberculosis to MAIT cells.

This study identifies ULK1-driven autophagy as a mechanism by which HPV+ HNC cells degrade MHC-I, promoting immune evasion and tumor growth.

This study shows that C. neoformans infection increases glycolytic activity in fetal liver-derived alveolar-like macrophages, which is HIF1-dependent.

This study shows that omega-3 fatty acids and glucocorticoids synergistically suppress inflammatory gene expression in SLE macrophages, promoting a pro-resolving M2 phenotype and potentially reducing steroid dependence.

This study identifies host-pathogen genetic interactions influencing tuberculosis susceptibility using a genetically diverse mouse panel and Mtb mutants.

This study identifies CNBP as a regulator of c-Rel dependent IL-12β gene transcription and Th1 immunity, showing its role in macrophage function and resistance to toxoplasmosis.