Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression
Hyojin Kim, Eric B. Gao, Adam Draper, Noah Berens, Hanna Vihma, Xinyuan Zhang, Alexandra Higashi-Howard, Kimberly Ritola, Jeremy M. Simon, Andrew John Kennedy, Benjamin D. Philpot
This study shows that restoring Tcf4 expression in neurons of a PTHS mouse model improves behavioral and electrophysiological phenotypes.
eLife · Apr 27, 2022Peer-reviewedNeuroscience