Layer 5 anterior cingulate cortical neurons engage dorsolateral periaqueductal gray excitatory neurons to facilitate the affective component of pain
Jasmine Kaslow, William M. McCallum, Amaury François, Gregory F. Corder, Eric J. Kremer, Kimberly Ritola, Nicole Mercer Lindsay, Grégory Scherrer
The paper identifies a specific neural circuit between the ACC and dlPAG that facilitates the affective component of pain, showing its role in aversive behaviors beyond pain.
bioRxiv · Sep 1, 2026 · PreprintNeuroscience