Benjamin D. Philpot

This study identifies parvalbumin interneurons and dentate gyrus remodeling as key factors in epileptogenesis in Angelman syndrome model mice.

SORDINO improves fMRI in awake mice by being silent, sensitive, specific, and resistant to motion artifacts, enabling better brain activity mapping.

This study identifies disrupted O-GalNAc glycosylation as a mechanism and biomarker for SLC35A2-associated epilepsy using mouse models and human tissue analysis.

This study shows that restoring TCF4 in juvenile PTHS model mice only partially reverses behavioral phenotypes, highlighting a critical early window for effective treatment.

The paper identifies active human neural enhancers and CRISPRa gRNAs that upregulate NDD risk genes, providing a resource for cis-regulatory therapy development.

This study shows that restoring Tcf4 expression in neurons of a PTHS mouse model improves behavioral and electrophysiological phenotypes.

This study investigates how two types of interneurons modulate nonlinear synaptic integration in mouse visual cortex, finding that SOM interneurons reduce response amplitude while PV interneurons have minimal effects.

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.

The paper uses Collaborative Cross mice to identify genetic loci and candidate genes associated with epilepsy traits, providing resources for studying seizure outcomes and developing new therapies.

This study shows that axotomy leads to dendritic spine loss and presynaptic hyper-excitability in injured neurons, which can be normalized by exogenous netrin-1.

The paper compares mouse models of syndromic ASD with human ASD brain data to identify shared myelination and axon development disruptions across both syndromic and idiopathic ASD.