A multi-omic analysis of optineurin proteinopathy in a yeast model suggests the involvement of lipid metabolism in Amyotrophic Lateral Sclerosis
Daniel M. Bean, Silvia Hnatova, Michael Mülleder, Sandra Magalhães, Daniel J. H. Nightingale, Kathryn Susan Lilley, Markus Ralser, Alexandra Nunes, Brian James Goodfellow, Stephen G. Oliver
The paper uses a yeast model to analyze multi-omic data from OPTN overexpression, finding distinct genetic and metabolic responses to different ALS-linked genes.
bioRxiv · Apr 26, 2019 · PreprintSystems Biology