Daniel J. H. Nightingale

This study investigates caspase cleavage of Drosophila Sgg-PD proteoforms, revealing their role in cytoskeletal and cell junction regulation and unexpected retention of cleaved N-terminal domains.

This paper introduces a semi-supervised Bayesian method for protein sub-cellular localisation and novelty detection, identifying new compartments in proteomic data.

The paper characterizes protein isoforms of the Drosophila sgg gene, revealing distinct localization, interactions, and functions for different proteoforms during development.

The paper uses a yeast model to analyze multi-omic data from OPTN overexpression, finding distinct genetic and metabolic responses to different ALS-linked genes.

The paper analyzes transcriptional regulatory networks in yeast to identify novel features of gene regulation in protein transactions, finding that transcriptional regulation is underrepresented and controlled by few regulators.