Human pluripotent stem cell-derived macrophages modify development of human kidney organoids
Filipa M. Lopes, Ioannis Bantounas, Alexandra Sarov, Adrian S. Woolf, Susan J. Kimber
This study shows that adding human pluripotent stem cell-derived macrophages to kidney organoids affects their development, increasing glomeruli area but also causing growth inhibition and dysmorphic tissue when added in high numbers.
bioRxiv · Nov 7, 2025 · PreprintDevelopmental Biology