Adrian S. Woolf

This study shows that adding human pluripotent stem cell-derived macrophages to kidney organoids affects their development, increasing glomeruli area but also causing growth inhibition and dysmorphic tissue when added in high numbers.

This study identifies two progenitor sources for kidney lymphatics in mice: Tie2 endothelial lineage and Osr1 intermediate mesoderm, showing a dual origin for kidney lymphatic formation.

The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.

The paper analyzes clinical and mechanistic data from individuals with ACTB/ACTG1 variants to identify distinct disease phenotypes and molecular mechanisms of non-muscle actinopathies.

This paper demonstrates that AAV-mediated HPSE2 gene transfer improves bladder function in a mouse model of urofacial syndrome by restoring neurogenic relaxation.

This study uses HNF1B mutant kidney organoids to reveal molecular and physiological defects in dysplastic kidney malformations and identify potential therapeutic targets.

This study shows that Tshz3 haploinsufficiency in mice causes kidney structural, molecular, and functional abnormalities.