Injury-induced tau pathology promotes aggressive behavior in Drosophila without neurodegeneration.
Roilea Maxson, Christine J. Smoyer, Megan F Hampton, Yusheng Shen, Kailea Wiese, Cheryl Yee, Aishini Singh, Alexandria Funtila, Richard J. McKenney, Kassandra M Ori-McKenney
This study shows that injury-induced tau phosphorylation in Drosophila leads to aggressive behavior through dopaminergic circuit activation without causing neurodegeneration.
Proceedings of the National Academy of Sciences · Jun 30, 2026Peer-reviewedNeuroscience