Kassandra M Ori-McKenney

The paper introduces FlexENN, a graph neural network that predicts binding energies for both folded and intrinsically disordered protein complexes, showing improved performance over rigid-body methods.

The paper investigates how specific phosphorylation patterns of tau affect microtubule binding, cooperativity, and filament assembly in tauopathies, revealing that pattern, not level, drives filament formation.

This study shows that injury-induced tau phosphorylation in Drosophila leads to aggressive behavior through dopaminergic circuit activation without causing neurodegeneration.

The paper investigates intracellular transport pauses, finding they are active, motor-driven states rather than passive, and reveals a quantitative relationship between pause diffusivity and run velocity.

This study identifies MAP9 as a microtubule stabilizer that promotes neuronal morphogenesis and differentially regulates kinesin motor activity.

The paper identifies a universal stick-slip transport mechanism in cells, showing vesicle velocities follow a Gamma distribution across different environments.

This study shows that microtubule acetylation increases during cellular senescence and affects cytoplasmic health by altering transport and microtubule dynamics.

This study identifies N2G as an F-actin bundler and kinesin-1 activator that mediates active microtubule-actin crosstalk, crucial for nuclear positioning.

This study shows UNC-33 maintains neuronal microtubule arrays by promoting microtubule rescue, preventing loss and maintaining polarity in C. elegans neurons.