Structure-based recasting of a mammalian DNA transpososomeas an obligate heterodimer
Raju Mandal, Alison Burgess Hickman, Rhea Desai, Alexandria Primich, Fred Dyda
The paper determines the structure of a hyperactive transpososome and engineers an obligate heterodimeric system for targeted genomic integration.
bioRxiv · Jul 16, 2026 · PreprintMolecular Biology