Molecular BiologybioRxivPreprint
Structure-based recasting of a mammalian DNA transpososomeas an obligate heterodimer
Raju Mandal, Alison Burgess Hickman, Rhea Desai…·Fred Dyda
The paper determines the structure of a hyperactive transpososome and engineers an obligate heterodimeric system for targeted genomic integration.
DOI 10.64898/2026.07.15.738711