A reconstruction of the mammalian secretory pathway identifies mechanisms regulating antibody production
Helen O. Masson, Jasmine Tat, Pablo Di Giusto, Athanasios Antonakoudis, Isaac Shamie, Hratch Baghdassarian, Mojtaba Samoudi, Caressa M. Robinson, Chih‐Chung Kuo, Natalia Koga, Sonia Singh, Angel Gezalyan, Zerong Li, Alexia Movsessian, Anne Richelle, Nathan E. Lewis
The paper presents secRecon, a comprehensive secretory pathway reconstruction, and uses it to identify secretory differences in plasma cells and CHO cells, highlighting potential targets for improving secretion capacity.
Cell Systems · Dec 1, 2025Peer-reviewedSystems Biology