FOXO1 inhibition and FADD knockdown have opposing effects on anticancer drug-induced cytotoxicity and p21 expression in osteosarcoma
Danielle Walker, Antanay Hall, Alexis Bonwell, Nancy Beatriz Gordon, Danielle Robinson, Mario G. Hollomon
This study shows FOXO1 inhibition reduces anticancer drug cytotoxicity and increases p21, while FADD knockdown enhances cytotoxicity and reverses p21 upregulation in osteosarcoma.
bioRxiv · Sep 20, 2025 · PreprintCancer Biology