α-Synuclein pre-formed fibrils induce prion-like protein aggregation and neurotoxicity in C. elegans models of Parkinson's disease
Merry Chen, Julie Vincent, Alexis Ezeanii, Saurabh C. Wakade, Shobha D. Yerigenahally, Danielle E. Mor
This study uses C. elegans to show that α-synuclein pre-formed fibrils induce prion-like aggregation and neurotoxicity, with protective effects from targeting heparan sulfate proteoglycan biosynthesis.
bioRxiv · Nov 11, 2021 · PreprintNeuroscience