Author

Merry Chen

Augusta University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexis Ezeanii· 1 shared Danielle E. MoriD· 1 shared Dean P. JonesiD· 1 shared Douglas Ian WalkeriD· 1 shared Fion K. Lau· 1 shared Gary Wright MilleriD· 1 shared Joshua M. Bradner· 1 shared Julie Vincent· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Alexis Ezeanii

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2 papers

Recent·Most cited

α-Synuclein pre-formed fibrils induce prion-like protein aggregation and neurotoxicity in C. elegans models of Parkinson's disease

Merry Chen, Julie Vincent, Alexis Ezeanii, Saurabh C. Wakade, Shobha D. Yerigenahally, Danielle E. Mor

This study uses C. elegans to show that α-synuclein pre-formed fibrils induce prion-like aggregation and neurotoxicity, with protective effects from targeting heparan sulfate proteoglycan biosynthesis.

bioRxiv · Nov 11, 2021 · PreprintNeuroscience

Genetic or toxicant induced disruption of vesicular monoamine storage and global metabolic profiling in Caenorhabditis elegans

Joshua M. Bradner, Vrinda Kalia, Fion K. Lau, Monica Sharma, Meghan L. Bucher, Michelle A. Johnson, Merry Chen, Douglas Ian Walker, Dean P. Jones, Gary Wright Miller

This study investigates the effects of reduced VMAT activity in C. elegans, showing increased sensitivity to MPP+ and metabolic changes, suggesting conserved monoamine function and potential for metabolomics in disease research.

Toxicological Sciences · Jan 22, 2021Peer-reviewedNeuroscience