Author

Alfonso Martinez Arias

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 6

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Research Focus:cell type annotation· 4 Approach:statistical model· 4 Approach:experimental assay· 3 Research Focus:trajectory inference· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2

Frequent Co-Authors

Pau RuéiD· 4 shared David A Turner· 2 shared Jonathan P Mackenzie· 2 shared Anne Grapin-Botton· 1 shared Benjamin Steventon· 1 shared Christian Schröter· 1 shared David Andrew Turner· 1 shared Eleanor Davies· 1 shared

Activity by Year

2014-2017 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersDevelopmental Biology

Pau RuéORCID

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6 papers

Recent·Most cited

Evo-engineering and the Cellular and Molecular Origins of the Vertebrate Spinal Cord

Benjamin Steventon, Alfonso Martinez Arias

This paper reviews lineage studies across vertebrate models to explore how spinal cord formation arises from conserved gene regulatory networks and proposes a dynamical systems approach to understand developmental diversity.

Developmental Biology · Dec 1, 2017Peer-reviewedDevelopmental Biology

FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in ES cells

Christian Schröter, Pau Rué, Jonathan P Mackenzie, Alfonso Martinez Arias

The paper identifies FGF/MAPK signaling's role in setting the threshold for a bistable circuit that controls cell fate decisions between epiblast and primitive endoderm in ES cells.

Development · Jan 1, 2015Peer-reviewedDevelopmental Biology

A framework for the analysis of symmetric and asymmetric divisions in developmental processes

Pau Rué, Yung Hae Kim, Hjalte List Larsen, Anne Grapin-Botton, Alfonso Martinez Arias

The paper proposes a model of progenitor priming to explain how sibling cells' division modes are linked, leading to an excess of symmetric divisions in development.

bioRxiv · Oct 28, 2014 · PreprintDevelopmental Biology

Brachyury cooperates with Wnt/β-Catenin signalling to elicit Primitive Streak like behaviour in differentiating mouse ES cells.

David Andrew Turner, Pau Rué, Jonathan P Mackenzie, Eleanor Davies, Alfonso Martinez Arias

This study shows that Brachyury and Wnt/β-Catenin signaling work together to drive primitive streak-like behavior in differentiating mouse ES cells through EMT and cell motility.

BMC Biology · Aug 13, 2014Peer-reviewedDevelopmental Biology

An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells

David A Turner, Jamie Trott, Penelope Hayward, Pau Rué, Alfonso Martinez Arias

This study investigates how extracellular signaling and pluripotency loss dynamics influence cell fate decisions in mouse ES cells, finding that Wnt signaling supports both neuroectoderm and primitive streak fates.

Biology Open · Jun 20, 2014Peer-reviewedDevelopmental Biology

Generation of Aggregates of Mouse ES Cells that Show Symmetry Breaking, Polarisation and Emergent Collective Behaviour in vitro.

Peter Baillie-Johnson, Susanne C van den Brink, Tina Balayo, David A Turner, Alfonso Martinez Arias

This paper describes a method to generate mouse ES cell aggregates that exhibit symmetry breaking, polarization, and collective behavior in vitro.

bioRxiv · May 19, 2014Developmental Biology