Pau Rué

The paper identifies FGF/MAPK signaling's role in setting the threshold for a bistable circuit that controls cell fate decisions between epiblast and primitive endoderm in ES cells.

The paper proposes a model of progenitor priming to explain how sibling cells' division modes are linked, leading to an excess of symmetric divisions in development.

This study shows that Brachyury and Wnt/β-Catenin signaling work together to drive primitive streak-like behavior in differentiating mouse ES cells through EMT and cell motility.

This study investigates how extracellular signaling and pluripotency loss dynamics influence cell fate decisions in mouse ES cells, finding that Wnt signaling supports both neuroectoderm and primitive streak fates.