Disruption of DLL4/NOTCH1 Causes Dysregulated PPARγ/AKT Signaling in Pulmonary Arterial Hypertension
Keytam S. Awad, Shuibang Wang, Edward J. Dougherty, Ali Keshavarz, Cumhur Y. Demirkale, Zu Xi Yu, Latonia Miller, Jason M. Elinoff, Robert L. Danner
This study shows that DLL4/NOTCH1 signaling regulates PPARγ/AKT pathways in PAH, with potential therapeutic implications for vascular remodeling.
bioRxiv · Jan 31, 2024Cell Biology