Tumor Priming by Ultrasound Mechanogenetics for with SynNotch CAR T Therapy
Chi Woo Yoon, Chunyang Song, Dung Ngo Minh Nguyen, Linshan Zhu, Phuong Ho, Ziliang Huang, Gengxi Lu, Ali Zamat, Alexa Lewis, Ruimin Chen, Yushun Zeng, Nan Sook Lee, Christina A. M. Jamieson, Koping Kirk Shung, Qifa Zhou, Yingxiao Wang
This paper develops a system using ultrasound to remotely stimulate gene expression in tumors, enabling precise CAR T cell activation for immunotherapy.
bioRxiv · Oct 1, 2024 · PreprintSynthetic Biology